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Hidden reach of the micromanagers
Peter S Linsley1, Aimee L Jackson
1Regulus Therapeutics, 1896 Rutherford Road, Carlsbad, CA 92008, USA. plinsley@regulusrx.com
BMC Biology
|June 10, 2010
Abstract:
Small interfering RNAs can trigger unintended, microRNA-like off-target effects, but the impact of these effects on functional studies has been controversial. A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens.
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