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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells

Youquan Bu1, Yusuke Suenaga, Rintaro Okoshi

  • 1Division of Biochemistry and Anti-tumor Research, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan.

Biochemical and Biophysical Research Communications
|June 10, 2010
PubMed

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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