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Updated: Jun 12, 2026

Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
Synthesis and in vitro evaluation of 18F labeled tyrosine derivatives as potential positron emission tomography (PET)
Limin Wang1, Wenchao Qu, Brian Lieberman
1Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract:
Three new 18F labeled fluoroalkyl tyrosine derivatives, O-(2-[18F]fluoroethyl)-alpha-methyltyrosine (FEMT, [18F]2), O-(2-[18F]fluoroethyl)-2-L-azatyrosine (FEAT, [18F]3), O-(2-[18F]fluoroethyl)-L-tyrosineamide (FETA, [18F]4) have been synthesized and radiofluorinated with 5-34% decay-corrected yield. In vitro studies were carried out in U-138 MG human glioblastoma. Cellular uptake of new tracers was compared to clinically utilized imaging agent O-(2-[18F]fluoroethyl)-L-tyrosine (FET, [18F]1). The uptake of tracers followed the order of FET ([18F]1) > FEAT([18F]3) > FEMT ([18F]2) approximately FETA ([18F]4).
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