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Potential-well model in acoustic tweezers.

Shih-Tsung Kang¹, Chih-Kuang Yeh

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

|June 10, 2010

Summary

This study introduces an acoustic vortex tweezers model for non-contact particle manipulation. The model demonstrates effective transverse trapping between near and far fields, ideal for 2D manipulation and in vivo applications.

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Area of Science:

Acoustic manipulation
Biophysics
Microfluidics

Background:

Standing-wave acoustic tweezers are widely used for non-invasive particle manipulation.
Their penetration in biological tissues shows promise for in vivo applications.

Purpose of the Study:

To propose and analyze an acoustic-vortex-based trapping model for acoustic tweezers.
To investigate the trapping properties and potential for 2D manipulation, especially in vivo.

Main Methods:

A four-element 1-MHz planar transducer generated acoustic waves to create an acoustic vortex with an axial null.
Gor'kov's theory in the Rayleigh regime was applied to calculate potential energy and radiation force.
The trapping behavior of particles in the acoustic vortex was analyzed in both transverse and axial directions.

Main Results:

The acoustic vortex created potential wells in the transverse direction, driving particles towards the beam axis.
Effective trapping occurred in a specific region between the near-field interference and the well-constructed far-field.
A maximum trapping force of 50.0 pN was observed for a 13-μm polystyrene sphere, with potential for trapping ~10^6 particles per plane.

Conclusions:

The acoustic vortex model provides effective transverse trapping and a long working distance, suitable for 2D manipulation.
The ideal trapping distance is suggested to be within one-fourth of the Rayleigh distance.
The model shows significant potential for in vivo applications due to its non-contact and non-invasive nature.