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Cerebral venous sinus thrombosis in 2 children with celiac disease

Murat Doğan1, Erdal Peker, Sinan Akbayram

  • 1Department of Pediatrics, School of Medicine, Yuzuncu Yil University, Van, Turkey. doganmurat.md@gmail.com

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|June 10, 2010
PubMed

Insights

Celiac disease (CD) may cause cerebral venous sinus thrombosis (CVST) in children, even without digestive symptoms. Investigating CD in children with CVST could improve diagnosis and management.

Area of Science:

  • Pediatric Neurology
  • Gastroenterology
  • Immunology

Background:

  • Cerebral venous sinus thrombosis (CVST) is a rare but serious condition in children, with an incidence of 0.67 per 100,000 annually.
  • Identified risk factors for childhood CVST include head trauma, infections, malignancies, and autoimmune disorders.
  • Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion, primarily affecting the small intestine.

Observation:

  • This report details two pediatric cases of CVST in conjunction with celiac disease.
  • The affected patients were a 16-year-old boy and a 2-year-old boy.
  • Notably, neither patient presented with typical gastrointestinal symptoms associated with celiac disease.

Findings:

  • The cases highlight a potential, albeit uncommon, association between celiac disease and cerebral venous sinus thrombosis in pediatric patients.
  • Celiac disease should be considered in the differential diagnosis of CVST, irrespective of the presence of gastrointestinal manifestations.
  • Neurological disorders, including stroke, have been previously linked to celiac disease.

Implications:

  • The findings suggest that screening for celiac disease may be warranted in children diagnosed with cerebral venous sinus thrombosis.
  • Integrating celiac disease investigation into the diagnostic algorithm for CVST could lead to earlier identification and treatment.
  • This association broadens the understanding of potential extra-intestinal manifestations of celiac disease in pediatric populations.

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