Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Factors Affecting Respiration01:24

Factors Affecting Respiration

Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Requirements for Human Life01:26

Requirements for Human Life

The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RETRACTED: Zito Marino et al. AXL and MET Tyrosine Kinase Receptors Co-Expression as a Potential Therapeutic Target in Malignant Pleural Mesothelioma. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1993.

Journal of personalized medicine·2026
Same author

Plantar basal cell carcinoma: a rare location.

Italian journal of dermatology and venereology·2026
Same author

Post-mortem microbiology (PMM) as diagnostic tool in sudden unexpected childhood deaths.

Legal medicine (Tokyo, Japan)·2026
Same author

Evolution of hematopoietic stem cell potential from preterm to term neonates.

HemaSphere·2026
Same author

Correction: Mosca et al. Sarcoma Common MHC-I Haplotype Restricts Tumor-Specific CD8+ T Cell Response. <i>Cancers</i> 2022, <i>14</i>, 3414.

Cancers·2026
Same author

Metastatic Syringocystadenocarcinoma Papilliferum Treated with Enzalutamide: A Case Report and a Review of the Literature.

Case reports in dermatology·2026

Related Experiment Video

Updated: Jun 12, 2026

Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography
08:51

Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography

Published on: August 12, 2014

Does pulmonary function change during whole-body deep hypothermia?

Giacomo Cavallaro1, Luca Filippi, Gloria Cristofori

  • 1Neonatal Intensive Care Unit, Fondazione IRCCS Cà' Granda-Ospedale Maggiore Policlinico, University Department of Mother and Infant Sciences, University of Milan, Milan, Italy. giacomo.cavallaro@mangiagalli.it

Archives of Disease in Childhood. Fetal and Neonatal Edition
|June 10, 2010
PubMed
Summary
This summary is machine-generated.

Deep hypothermia (DH) and mild hypothermia (MH) show similar effects on respiratory function in newborns with hypoxic-ischaemic encephalopathy. Both therapeutic cooling methods maintained adequate oxygenation and ventilation support without significant differences.

More Related Videos

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Related Experiment Videos

Last Updated: Jun 12, 2026

Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography
08:51

Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography

Published on: August 12, 2014

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Area of Science:

  • Neonatal Medicine
  • Therapeutic Hypothermia
  • Respiratory Physiology

Background:

  • Whole-body deep hypothermia (DH) is being explored as a therapeutic strategy for newborns with hypoxic-ischaemic encephalopathy (HIE).
  • Understanding the impact of DH on respiratory function compared to mild hypothermia (MH) is crucial for clinical application.

Purpose of the Study:

  • To compare the effects of deep hypothermia (core temperature 30-33°C) versus mild hypothermia (core temperature 33-34°C) on respiratory function in asphyxiated newborns.
  • To evaluate respiratory parameters in neonates undergoing different levels of therapeutic hypothermia.

Main Methods:

  • Observational pilot study involving 57 newborns with moderate-to-severe HIE and gestational age ≥36 weeks.
  • Patients were divided into two groups: DH (n=29) and MH (n=28).
  • Mechanical ventilation was adjusted to maintain SaO2 between 92-95%.

Main Results:

  • No significant differences were observed in the duration of oxygen and ventilation support between DH and MH groups.
  • Respiratory rate and PaCO2 levels were similar across both hypothermia groups.
  • Key ventilator parameters including FiO2, peak inspiratory pressure, PEEP, minute ventilation, and tidal volume were comparable between DH and MH.

Conclusions:

  • Deep hypothermia and mild hypothermia result in similar pulmonary function in asphyxiated newborns.
  • Both DH and MH appear to be safe regarding respiratory support requirements in this patient population.