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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: Jun 12, 2026

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Increased iris thickness and association with primary angle closure glaucoma.

B-S Wang1, A Narayanaswamy, N Amerasinghe

  • 1Singapore Eye Research Institute and Singapore National Eye Center, Singapore.

The British Journal of Ophthalmology
|June 10, 2010
PubMed
Summary
This summary is machine-generated.

Increased iris thickness is a key indicator for angle closure disease. This study found thicker irises in patients with angle closure, suggesting a potential diagnostic marker for this glaucoma subtype.

Related Experiment Videos

Last Updated: Jun 12, 2026

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Anterior Segment Imaging

Background:

  • Angle closure disease is a significant cause of vision loss.
  • Quantitative iris parameters are not well-established diagnostic markers for angle closure.

Purpose of the Study:

  • To investigate the relationship between quantitative iris parameters and angle closure disease.
  • To assess the diagnostic value of iris thickness and area measurements.

Main Methods:

  • Prospective recruitment of participants with angle closure from glaucoma clinics.
  • Anterior segment optical coherence tomography (AS-OCT) performed under standardized dark conditions.
  • Customised software used to measure iris thickness at 750 µm (IT750) and 2000 µm (IT2000) from the scleral spur, maximal iris thickness (ITM), and cross-sectional iris area (I-Area).

Main Results:

  • 167 eyes with angle closure (PAC, PACG, fellow eyes) and 1153 normal eyes examined.
  • Significantly greater mean IT750, IT2000, ITM, and I-Area in angle closure eyes compared to normal eyes after adjusting for covariates (p<0.001 for thickness measures).
  • Multivariate analysis showed increased odds of angle closure with greater iris thickness (ORs ranging from 1.7 to 2.2 per 0.1 unit increase).

Conclusions:

  • Increased iris thickness is significantly associated with angle closure disease.
  • Quantitative iris parameters, particularly thickness, may serve as valuable biomarkers for identifying individuals at risk of angle closure.