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Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm

Jonathan Golledge1, Reinhold Muller, Paula Clancy

  • 1Vascular Biology Unit, School of Medicine and Dentistry, James Cook University, Townsville QLD 4811, Australia. jonathan.golledge@jcu.edu.au

European Heart Journal
|June 10, 2010
PubMed

Insights

Plasma D-dimer shows significant potential for diagnosing abdominal aortic aneurysm (AAA) and predicting its growth. Elevated levels strongly correlate with AAA presence and progression, aiding in risk stratification.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Vascular Surgery

Background:

  • Abdominal aortic aneurysm (AAA) diagnosis and risk stratification lack comprehensive tools.
  • Plasma biomarkers are increasingly investigated for their role in AAA.

Purpose of the Study:

  • To evaluate the diagnostic and prognostic value of plasma D-dimer in abdominal aortic aneurysm (AAA).
  • To assess the potential of plasma D-dimer for stratifying AAA risk and progression.

Main Methods:

  • Multivariate regression, receiver operator characteristic, and classification and regression tree (CART) analyses were employed.
  • Plasma D-dimer levels were assessed in 1260 population screening subjects and 132 referral clinic patients.
  • AAA growth was monitored via ultrasound in 299 population subjects over a median of 5.5 years.

Main Results:

  • Plasma D-dimer was the dominant risk factor for AAA presence in both study groups.
  • Cut-off values of >400 ng/mL and >900 ng/mL showed significantly elevated odds ratios for AAA.
  • CART analyses confirmed D-dimer's role in defining extreme AAA risk groups (3% to 82% prevalence).
  • Higher D-dimer levels were significantly associated with faster AAA growth (0.4 to 2.5 mm/year).

Conclusions:

  • Plasma D-dimer demonstrates significant diagnostic and prognostic capabilities for abdominal aortic aneurysm (AAA).
  • D-dimer can effectively stratify risk for AAA presence and predict its growth rate.
Abstract

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