Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Chronotherapy of tenoxicam].

A Reinberg1, R Manfredi, M F Kahn

  • 1Fondation A. de Rothschild, CNRS, URA 581, Paris.

Therapie
|March 1, 1991
PubMed
Summary

This study explored the optimal dosing time for tenoxicam, a nonsteroidal anti-inflammatory drug (NSAID), in arthritis patients. Maximum pain relief and stiffness reduction were observed when tenoxicam was administered at midday.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hours of changing responsiveness or susceptibility.

Perspectives in biology and medicine·2015
Same author

Commemoration Erhard Haus, M.D., Ph.D.

La Clinica terapeutica·2013
Same author

[Circadian rhythms in the toxic effects of the histamine antagonist cetirizine in mice].

Pathologie-biologie·2005
Same author

Role of school schedule, age, and parental socioeconomic status on sleep duration and sleepiness of Parisian children.

Chronobiology international·2002
Same author

Analysis of circadian and ultradian rhythms of skin surface properties of face and forearm of healthy women.

The Journal of investigative dermatology·2001
Same author

[Utilization of a self-contained psychometry-oriented device, for study of affective and cognitive function of a subject].

L'Encephale·1999

Area of Science:

  • Pharmacology
  • Rheumatology
  • Chronobiology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for arthritis management.
  • The efficacy of NSAIDs can be influenced by the timing of administration (chronotherapy).
  • Tenoxicam is an NSAID used for inflammatory joint conditions.

Purpose of the Study:

  • To investigate the chronotherapy of tenoxicam in patients with ankylosing spondylitis, rheumatoid arthritis, and osteoarthritis of the hip.
  • To determine the optimal once-a-day dosing time for tenoxicam to maximize therapeutic efficacy.
  • To assess the impact of dosing time on pain and stiffness in arthritis patients.

Main Methods:

  • A study was conducted to evaluate the effects of tenoxicam administration at different times of the day.

Related Experiment Videos

  • Patient outcomes, including pain and stiffness, were measured to assess efficacy.
  • The study focused on patients diagnosed with ankylosing spondylitis, rheumatoid arthritis, and hip osteoarthritis.

    • Main Results:

    • Variations in therapeutic efficacy were observed based on the timing of tenoxicam administration.
    • Maximum efficacy for both pain relief and reduction of stiffness was achieved when tenoxicam was administered at 8 am or 12 pm.
    • The drug demonstrated good tolerance across all tested dosing times.

    Conclusions:

    • Midday administration (12 pm) is recommended as the optimal once-a-day dosing time for tenoxicam.
    • Chronotherapy plays a significant role in optimizing NSAID efficacy for inflammatory arthritis.
    • Further research into chronotherapy can enhance patient outcomes for musculoskeletal conditions.