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Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central
B Predieri1, S Luisi, E Casarosa
1Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy. barbara.predieri@unimore.it
Journal of Endocrinological Investigation
|June 10, 2010
Summary
Allopregnanolone levels in girls with central precocious puberty (CPP) differ based on stimulation type. Gonadal production is suggested, aiding CPP diagnosis.
Area of Science:
- Endocrinology
- Pediatric Endocrinology
- Neuroendocrinology
Background:
- Allopregnanolone, a neuroactive steroid, is implicated in central precocious puberty (CPP).
- Elevated baseline allopregnanolone levels are observed in girls with CPP.
- Previous tests suggest both adrenal and ovarian contribution to allopregnanolone production.
Purpose of the Study:
- To assess allopregnanolone concentrations following GnRH and GnRH agonist analog stimulation in girls with CPP.
- To elucidate the primary source of allopregnanolone secretion in CPP.
Main Methods:
- Evaluation of gonadotropins and steroid hormones in 15 girls with CPP.
- Administration of GnRH and triptorelin (GnRH agonist analog) stimulation tests.
- Measurement of allopregnanolone, LH, FSH, estradiol, and DHEAS levels post-stimulation.
Main Results:
- GnRH stimulation led to significant increases in LH, FSH, and allopregnanolone.
- Triptorelin administration resulted in significant increases in LH, FSH, estradiol, and DHEAS.
- Triptorelin administration caused a significant decrease in allopregnanolone levels.
Conclusions:
- Differential allopregnanolone response to GnRH and its agonist analog suggests varying mechanisms of action.
- Data indicate a predominant gonadal source for allopregnanolone in CPP subjects.
- Allopregnanolone measurement may be a valuable diagnostic tool for CPP.
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