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Updated: Jun 12, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
Published on: April 21, 2014
Approach to incidentally diagnosed isolated ventricular noncompaction of myocardium
Sravanthi Nagavalli1, James L Vacek
1Mid America Cardiology and Section of Cardiovascular Diseases, The University of Kansas Hospital and Medical Center, Kansas City, KS 66160, USA. jlvacek@mac.md
Abstract:
Isolated ventricular noncompaction (IVNC) is a congenital cardiomyopathy characterized by a distinctive ("spongy") morphological appearance of the left ventricular (LV) myocardium. It is rare but, with improved imaging modalities and awareness, it is being reported more frequently. Clinical manifestations may range from being asymptomatic to heart failure, arrhythmias, sudden cardiac death, and systemic thromboembolism. With the increasing reporting frequency, the implications of incidentally diagnosed noncompaction need to be addressed. We came across two cases at our medical center which raised important practical questions.
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