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Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Lipid Catabolism01:25

Lipid Catabolism

Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...

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Related Experiment Video

Updated: Jun 12, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Adipose tissue lipolysis.

Catherine-Ines Kolditz1, Dominique Langin

  • 1Inserm, Unité 858, Obesity Research Laboratory, Rangueil Institute of Molecular Medicine (I2MR), IFR150, Toulouse, France.

Current Opinion in Clinical Nutrition and Metabolic Care
|June 10, 2010
PubMed
Summary

Recent discoveries reveal complex regulation of adipose tissue lipolysis, involving new molecular actors beyond traditional hormones. Understanding these mechanisms offers potential therapeutic targets for obesity-related metabolic disorders.

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Last Updated: Jun 12, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

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Published on: July 21, 2017

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Assessing Whole-Body Lipid-Handling Capacity in Mice

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Area of Science:

  • Metabolic Regulation
  • Adipose Tissue Biology
  • Lipid Metabolism

Background:

  • Adipose tissue lipolysis is vital for energy homeostasis via triglyceride breakdown and fatty acid release.
  • Understanding lipases and triglyceride hydrolysis has revealed significant complexity in recent years.

Purpose of the Study:

  • To review recent discoveries in the lipolytic pathway.
  • To describe the regulatory mechanisms of adipose tissue lipolysis.

Main Methods:

  • Literature review of recent scientific discoveries.
  • Analysis of molecular actors and regulatory mechanisms.

Main Results:

  • Progress in understanding lipolytic enzyme roles and activation mechanisms.
  • Identification of additional molecular actors influencing lipolysis.
  • Major regulators include catecholamines, natriuretic peptides, and insulin.
  • Autocrine/paracrine factors like metabolites and prostaglandins may also play a role.

Conclusions:

  • Lipolysis manipulation holds therapeutic potential for obesity-related metabolic disorders.
  • Further unraveling regulatory events may identify novel therapeutic targets.