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Therapeutic keratoplasty for microbial keratitis
Namrata Sharma1, Ritika Sachdev, Vishal Jhanji
1R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Australia. namrata103@hotmail.com
Current Opinion in Ophthalmology
|June 10, 2010
Summary
Therapeutic keratoplasty effectively treats microbial keratitis, offering a high cure rate for bacterial infections. Advances in lamellar techniques and antimicrobial therapies improve outcomes, though graft survival remains challenging.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Infectious Diseases
Background:
- Microbial keratitis requires prompt management to prevent vision loss.
- Therapeutic keratoplasty is reserved for cases refractory to medical treatment.
- Maintaining globe integrity and eliminating infection are primary goals.
Purpose of the Study:
- To review recent literature (past 2 years) on therapeutic keratoplasty.
- To update on various aspects of this surgical procedure.
- To highlight recent advances and challenges.
Main Methods:
- Literature review of peer-reviewed articles.
- Analysis of therapeutic keratoplasty outcomes.
- Focus on recent surgical techniques and antimicrobial therapies.
Main Results:
- High microbiological cure rates (up to 100%) for bacterial keratitis.
- Recurrence concerns persist for fungal and Acanthamoeba keratitis.
- Lamellar keratoplasty and corneal debulking show promise.
- Intensive postoperative care is crucial for graft success.
Conclusions:
- Therapeutic keratoplasty is vital for refractory microbial keratitis.
- Lamellar keratoplasty offers an alternative to full-thickness grafts.
- Advances improve microbiological cure and visual outcomes, but graft survival remains a challenge.
