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Updated: Jun 12, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Patient preferences for next generation neural prostheses to restore bladder function.

P M H Sanders¹, M J Ijzerman, M J Roach

¹Department of Health Technology and Services Research, University of Twente, Enschede, The Netherlands.

|June 10, 2010

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Individuals with spinal cord injury (SCI) prefer neural prostheses (NP) that minimize side effects and maximize bladder function. Rhizotomy-free sacral root stimulation was the most preferred NP type, highlighting the need for user-centered design in SCI treatments.

Area of Science:

Neuroscience
Biomedical Engineering
Rehabilitation Medicine

Background:

Spinal cord injury (SCI) significantly impacts bladder function, necessitating advanced treatment solutions.
Neural prostheses (NP) offer potential for restoring bladder control, but patient preferences for specific features remain underexplored.

Purpose of the Study:

To determine patient utility weights for various neural prostheses (NP) treatment characteristics.
To assess overall patient preference among three types of NPs: Brindley, rhizotomy-free Brindley, and pudendal nerve stimulation.

Main Methods:

A choice-based conjoint (CBC) analysis survey was administered to 66 individuals with SCI.
Six attributes with three levels each were used to create choice sets for treatment scenarios.

Related Experiment Videos

Last Updated: Jun 12, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Multinomial logit modeling and hierarchical Bayes were employed to estimate individual part-worth utilities.

Main Results:

Side effects significantly influenced patient choices, followed by effectiveness in continence and voiding.
Rhizotomy-free sacral root stimulation NPs were preferred by 45% of participants.
Pudendal afferent nerve stimulation and sacral root stimulation with rhizotomy were preferred by 39% and 53% respectively, with nearly 20% expressing reluctance to use an NP continuously.

Conclusions:

Choice-based conjoint (CBC) analysis is a valuable tool for guiding the design of neural prostheses (NP).
Patients prioritize NPs offering complete bladder function with minimal invasiveness, no side effects, and user-friendly operation (e.g., button-operated, no frequent recharging).