Related Experiment Videos
Aspergilloma in sarcoidosis.
Jagruti Hede1, Rahul Bahot, J R Shah
1Department of Chest Diseases, Jaslok Hospital and Research Centre, Mumbai - 400 026, India.
Lung India : Official Organ of Indian Chest Society
|June 10, 2010
Summary
This case report details a patient with a 30-year history of sarcoidosis and tuberculosis. It highlights the progression of sarcoidosis to advanced fibrocystic disease and the subsequent development of aspergilloma.
Area of Science:
- Pulmonology
- Infectious Diseases
- Case Reports
Background:
- Sarcoidosis is a multisystem inflammatory disease of unknown cause.
- Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis.
- Co-occurrence of sarcoidosis and tuberculosis presents diagnostic and therapeutic challenges.
Purpose of the Study:
- To report a unique case of a patient with a long-term history of sarcoidosis and tuberculosis.
- To illustrate the complex interplay between these two granulomatous diseases.
- To highlight the diagnostic and management considerations in such cases.
Main Methods:
- Longitudinal case report of a 48-year-old male patient.
- Review of medical history spanning nearly 30 years.
- Documentation of disease progression, treatment interventions, and complications.
Main Results:
- Initial diagnosis of sarcoidosis at age 18, followed by remission after 8 years of treatment.
- Development of sputum-positive tuberculosis 10 years later, successfully treated.
- Progression of sarcoidosis to stage IV fibrocystic disease.
- Detection of aspergilloma in a sarcoid cystic cavity during an episode of massive hemoptysis.
Conclusions:
- The long-term course of sarcoidosis can be complicated by superimposed infections like tuberculosis.
- Advanced fibrocystic sarcoidosis creates a substrate for opportunistic infections such as aspergilloma.
- This case underscores the importance of vigilant monitoring and comprehensive management in patients with chronic granulomatous lung diseases.
Related Concept Videos
01:23Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
01:14Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...