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Published on: November 6, 2019
Pre-incisional infiltration of tonsils with dexamethasone dose not reduce posttonsillectomy vomiting and pain in
Kamran Montazeri1, Ahmad Okhovat, Azim Honarmand
1Department of Anesthesiology and Intensive Care Medicine, Isfahan, Iran.
Insights
Preincisional dexamethasone infiltration did not significantly reduce postoperative pain or vomiting in children after tonsillectomy. Further research is needed to confirm its limited role in tonsillectomy recovery.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Pharmacology
Background:
- Dexamethasone shows prophylactic effects against postoperative vomiting and pain in pediatric tonsillectomy.
- Limited research exists on the preemptive analgesic effects of dexamethasone post-tonsillectomy.
Purpose of the Study:
- To evaluate the efficacy of pre-incisional tonsil infiltration with dexamethasone on postoperative pain and vomiting in children undergoing tonsillectomy.
Main Methods:
- A double-blind study randomized 62 pediatric patients to receive peritonsillar dexamethasone or saline infiltration before surgery.
- Pain and vomiting incidence, antiemetic use, and analgesic consumption were compared using various pain scales.
Main Results:
- No statistically significant differences were observed between the dexamethasone and placebo groups regarding pain scores, nausea, vomiting, irritability, or analgesic requirements.
- Demographic data were similar between the two study groups.
Conclusions:
- Pre-incisional tonsillar infiltration with dexamethasone appears to have a limited role in the recovery phase following tonsillectomy.
- Further prospective, randomized studies are recommended to validate these findings.
Background And Objective:
Recently, dexamethasone has been found to have a prophylactic effect on postoperative vomiting and pain in children undergoing tonsillectomy. However, few studies have examined the preemptive analgesic effects of dexamethasone after tonsillectomy. The aim of this study was to evaluate the effect of pre-incisional infiltration of tonsils with dexamethasone on the incidence and severity of postoperative pain and vomiting in children undergoing tonsillectomy under general anesthesia.
Materials And Methods:
In a double blinded study, 62 patients were randomly allocated to infiltrate dexamethasone (0.5 mg/kg, maximum dose, 12 mg) or an equivalent volume of saline at the peritonsillar region. All infiltrations were performed following the induction of general anesthesia and 5 minutes prior to the onset of surgery. Anesthetic agents, end-tidal carbon dioxide levels, and the administration of intravenous fluids were carefully regulated. Surgery was performed by one attending otolaryngologists using the same dissection and snare technique. The incidence of pain and vomiting, need for rescue antiemetics, and analgesic consumption were compared in both groups. Pain scores used included Children's Hospital Eastern Ontario Pain Scale, "faces", and a 0-10 visual analogue pain scale.
Results:
Demographics of dexamethasone and placebo groups were similar. No statistically significant difference was found between the dexamethasone and placebo groups in pain score, nausea, vomiting, irritability, or analgesic requirement postoperatively.
Conclusion:
Preincisional infiltration of the tonsils with dexamethasone play a limited role in the recovery phase from tonsillectomy, but further prospective, randomized studies are needed to support it.
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