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Ovarian tumors with elevated CA-125 levels and severe juvenile hypothyroidism: a need for increased awareness
Sriram Krishnamurthy1, Anju Seth, Archana Puri
1Department of Pediatric Medicine, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, India. drsriramk@yahoo.com
Abstract:
A 15-yr-old girl presented with bilateral gross ovarian tumors, clinical features of long-standing unrecognized hypothyroidism and markedly elevated CA-125 levels. Ovarian resection was avoided, as the presentation was consistent with the Van Wyk and Grumbach syndrome; and the patient was treated with replacement of thyroid hormone. Regression of the ovarian tumors occurred 6 months after initiation of the treatment. The authors emphasise the need for increased awareness and screening for hypothyroidism in patients with ovarian tumors, in order to prevent inadvertent operative interventions.
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