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Physical growth in children with reflux nephropathy with normal or mildly impaired renal function

Sankar Kumar Das1, P S N Menon, A Bagga

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. sankr_das@rediffmail.com

Indian Journal of Pediatrics
|June 10, 2010
PubMed

Insights

Children with reflux nephropathy and vesicoureteric reflux (VUR) show impaired growth despite normal renal function. Elevated growth hormone with low IGF-1 suggests partial growth hormone insensitivity in these pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Growth Disorders

Background:

  • Reflux nephropathy and vesicoureteric reflux (VUR) are common in children.
  • Impaired growth is a potential complication in pediatric kidney diseases.
  • Understanding growth hormone dynamics is crucial for managing these conditions.

Purpose of the Study:

  • To investigate growth patterns and growth hormone-IGF-1 axis in children with reflux nephropathy and VUR.
  • To assess potential growth hormone insensitivity in this pediatric cohort.

Main Methods:

  • Study included ten children (11 months–10 years) with reflux nephropathy and VUR.
  • Assessed hematological, biochemical parameters, height standard deviation score (HZ score), and weight for height index (WHI).
  • Measured basal and stimulated peak growth hormone and insulin-like growth factor 1 (IGF-1) levels.

Main Results:

  • Children exhibited reduced HZ scores that decreased over 12 months.
  • Weight for height index (WHI) showed significant improvement during follow-up.
  • Elevated basal and stimulated growth hormone levels were observed, contrasted with low IGF-1 levels compared to controls.

Conclusions:

  • Children with reflux nephropathy and VUR may experience impaired linear growth.
  • The findings suggest partial insensitivity to growth hormone in this pediatric population.
  • Further research is warranted to explore therapeutic interventions for growth deficits.

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