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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Related Experiment Video

Updated: Jun 12, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Cannabinoids and bone: friend or foe?

Aymen I Idris1, Stuart H Ralston

  • 1Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Scotland, UK.

Calcified Tissue International
|June 10, 2010
PubMed
Summary

The endocannabinoid system regulates bone metabolism. Cannabinoid receptors (CB1, CB2) and GPR55 influence bone mass and remodeling, impacting osteoporosis and arthritis.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • The endocannabinoid system regulates physiological processes, including appetite, pain, and immunity.
  • Emerging evidence implicates the endocannabinoid system in bone metabolism regulation.
  • Cannabinoids interact with CB1, CB2, and GPR55 receptors to modulate cellular functions.

Purpose of the Study:

  • To investigate the role of cannabinoid receptors in bone metabolism and remodeling.
  • To explore the impact of cannabinoid receptor deficiency on skeletal phenotypes.
  • To assess the potential of cannabinoid receptor ligands in treating joint diseases.

Main Methods:

  • Skeletal phenotyping of mice with targeted inactivation of cannabinoid receptors (CB1, CB2, GPR55).
  • Pharmacological studies assessing the effects of cannabinoid receptor ligands.

Related Experiment Videos

Last Updated: Jun 12, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

  • Analysis of bone formation, resorption, and bone marrow fat accumulation.

    • Main Results:

    • CB1 deficiency leads to high peak bone mass but age-related osteoporosis due to impaired bone formation.
    • CB2 deficiency results in age-related osteoporosis with increased bone turnover.
    • GPR55 deficiency increases bone mass by impairing osteoclast resorptive activity.
    • Cannabinoid receptor ligands show efficacy in preclinical models of inflammatory arthritis.

    Conclusions:

    • Cannabinoid receptors and associated enzymes are crucial for bone remodeling.
    • Dysregulation of the endocannabinoid system contributes to osteoporosis and inflammatory joint diseases.
    • Targeting cannabinoid receptors offers potential therapeutic strategies for bone and joint disorders.