Formulation and evaluation of buccal patches for delivery of atenolol
Surya N Ratha Adhikari1, Bhabani S Nayak, Amit K Nayak
1Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore, Odisha-764002, India.
Abstract:
Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 P, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Various physicomechanical parameters like weight variation, thickness, folding endurance, drug content, moisture content, moisture absorption, and various ex vivo mucoadhesion parameters like mucoadhesive strength, force of adhesion, and bond strength were evaluated. An in vitro drug release study was designed, and it was carried out using commercial semipermeable membrane. All these fabricated patches were sustained for 24 h and obeyed first-order release kinetics. Ex vivo drug permeation study was also performed using porcine buccal mucosa, and various drug permeation parameters like flux and lag time were determined.
Related Concept Videos
Drug Delivery: Enteral Route
Drugs in...
Oral Drug Delivery Systems: Continuous-Release Systems
Oral Drug Delivery Systems: Introduction
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Modified-Release Drug Delivery Systems: Influencing Factors
Ophthalmic Drug Delivery Systems

