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Updated: Jun 12, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Iridium-catalyzed C-H activation versus directed ortho metalation: complementary borylation of aromatics and
Timothy E Hurst1, Todd K Macklin, Maike Becker
1Department of Chemistry, Queen's University, Kingston, Ontario, K7L 3N6 Canada.
Abstract:
Systematic studies are presented demonstrating the complementarity of directed ortho metalation (DoM) and Ir-catalyzed strategies for the provision of borylated aromatics and their subsequent Suzuki-Miyaura coupling reactions. A new concept, the use of the TMS group, readily introduced by DoM, as a latent regiodirective moiety to overcome the otherwise problematic production of isomeric borylated product mixtures is presented. Additional electrophile-induced ipso-deborylation and DoM reactions of the Bpin products are described.
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