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Related Experiment Videos

[Inspiratory phase angle behavior in oscilloresistometry].

A Barleben1, J Vogel, A Wilke

  • 1Forschungsinstitut für Lungenkrankheiten und Tuberkulose, Abt. Pathophysiologie, Berlin-Buch.

Zeitschrift Fur Erkrankungen Der Atmungsorgane
|January 1, 1991
PubMed
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Phase angle (PSI) during breathing differs in lung diseases. Pulmonary fibrosis shows PSI negativation, while emphysema shows stable PSI, linked to transpulmonary pressure (Ptp) variations.

Area of Science:

  • Respiratory physiology
  • Pulmonary mechanics

Context:

  • Oscillatory measurements of lung resistance, including phase angle (PSI), offer insights into respiratory mechanics.
  • Distinct PSI behaviors are observed during deep inspiration in pulmonary emphysema (unchanged) and pulmonary fibrosis (negativation).

Purpose:

  • To investigate the relationship between phase angle (PSI) and transpulmonary pressure (Ptp) during breathing in various lung conditions.
  • To explain the differing PSI findings in pulmonary emphysema and fibrosis.

Summary:

  • Transpulmonary pressure (Ptp) was measured alongside PSI in 85 subjects. PSI-negativation occurred in 31/43 pulmonary fibrosis patients and 10/19 healthy subjects, unlike emphysema patients with stable PSI.
  • Subjects with PSI-negativation exhibited higher Ptp at 100% total lung capacity (TLC), attributed to an overproportional pressure increase late in lung inflation.

Related Experiment Videos

  • A modified approach is proposed, analyzing PSI-volume (PSI-V) dependence separately in breathing ranges (mid-75% vital capacity and 75%-100% vital capacity) for improved noninvasive lung compliance assessment.

    • Impact:

    • This study enhances the noninvasive assessment of lung compliance by refining PSI-V dependence analysis.
    • Findings suggest PSI variations are influenced by heart rhythm and intrathoracic blood volume, offering further diagnostic potential.