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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Expanded infectious diseases screening program for Hispanic transplant candidates.

M A Fitzpatrick1, J C Caicedo, V Stosor

  • 1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|June 11, 2010
PubMed
Summary
This summary is machine-generated.

Enhanced infectious disease screening for Hispanic immigrants undergoing transplant evaluation identified significant rates of latent tuberculosis infection and Strongyloides stercoralis. Pre-transplant treatment was successful, minimizing post-transplant complications.

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Area of Science:

  • Infectious Diseases
  • Transplant Surgery
  • Immigrant Health

Background:

  • Pre-transplant screening guidelines often recommend testing for Strongyloides stercoralis and Trypanosoma cruzi.
  • The prevalence of these and other endemic infections in Hispanic immigrant populations awaiting transplantation is not well-documented.
  • Hispanic immigrants may have increased exposure to pathogens like Mycobacterium tuberculosis, S. stercoralis, Leishmania, and T. cruzi.

Purpose of the Study:

  • To assess the incidence of endemic infectious diseases in Hispanic immigrant transplant candidates.
  • To evaluate the effectiveness of expanded infectious disease screening and pre-transplant treatment.
  • To determine the impact of screening on post-transplant infectious complications.

Main Methods:

  • Prospective screening of 83 Hispanic immigrant transplant candidates from December 2006 to December 2008.
  • Expanded infectious disease screening included tests for Mycobacterium tuberculosis, S. stercoralis, Leishmania, and T. cruzi.
  • Treatment of identified infections prior to transplantation.

Main Results:

  • 20% of patients had latent tuberculosis infection (LTBI); 6.7% had serologic evidence of S. stercoralis infection.
  • Two patients had positive Leishmania titers and are under clinical observation.
  • All 14 transplanted patients are doing well post-transplant (average 348 days), with no evidence of screened pathogens after treatment.

Conclusions:

  • Expanded screening effectively identifies endemic infections in Hispanic immigrant transplant candidates.
  • Pre-transplant treatment of these infections is feasible and well-tolerated.
  • Targeted screening and treatment minimize post-transplant infectious complications in this population.