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Cardiac findings in Behçet's patients
Gulumser Heper1, Mualla Polat, Ertan Yetkin
1Department of Cardiology, AIB University, Bolu, Turkey. heperg@hotmail.com
International Journal of Dermatology
|June 11, 2010
Summary
Behçet's disease can affect the heart, causing structural changes and electrical instability. Cardiac involvement in Behçet's patients shows significant differences compared to the general population, potentially varying geographically.
Area of Science:
- Cardiology
- Rheumatology
- Internal Medicine
Background:
- Behçet's disease is a chronic, multi-system inflammatory disorder.
- Clinical manifestations and severity of Behçet's disease can exhibit geographic variations.
Purpose of the Study:
- To investigate cardiac findings in Behçet's disease patients.
- To compare cardiac parameters between Behçet's patients and a healthy control group.
- To identify potential geographic specificity of cardiac involvement in Behçet's disease.
Main Methods:
- Color-doppler and transesophageal echocardiography were utilized.
- Twelve-lead ECG recordings were used to calculate QT intervals and QT dispersion (QTd).
- Cardiac structure, function, and electrical activity were assessed and compared between groups.
Main Results:
- Behçet's patients exhibited significantly lower mean A velocity, prolonged DT, and prolonged IVRT, indicating diastolic dysfunction.
- Higher frequencies of atrial septal aneurysm, mitral valve prolapse/insufficiency, tricuspid valve insufficiency, and pulmonary hypertension were observed in Behçet's patients.
- While QTc time did not differ, QT dispersion (QTd) was significantly higher in Behçet's patients, suggesting electrical instability.
Conclusions:
- Cardiac involvement in Behçet's disease can impact cardiac structure, leading to diastolic dysfunction and electrical instability.
- Structural abnormalities such as valve issues and pulmonary hypertension are more prevalent in Behçet's patients.
- The observed cardiac involvement patterns may be geographically specific to Behçet's disease patients.
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