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Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...

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Related Experiment Video

Updated: Jun 12, 2026

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Lepr^db Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

The Sydney Diabetes Prevention Program: a community-based translational study.

Stephen Colagiuri¹, Philip Vita, Magnolia Cardona-Morrell

¹Boden Institute of Obesity, Nutrition and Exercise, University of Sydney, NSW, Australia. Stephen.colagiuri@sydney.edu.au

BMC Public Health

|June 11, 2010

Summary

This summary is machine-generated.

This study tested a community-based lifestyle intervention to prevent type 2 diabetes in at-risk adults. The program focused on weight loss, increased physical activity, and dietary changes, aiming for successful behavior modification.

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Last Updated: Jun 12, 2026

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Lepr^db Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

Area of Science:

Public Health
Preventive Medicine
Behavioral Science

Background:

Type 2 diabetes prevalence is rising in Australia, linked to increasing obesity.
Lifestyle modification is proven effective for type 2 diabetes prevention.
Translating evidence-based interventions into community settings is a key challenge.

Purpose of the Study:

To evaluate the reach, feasibility, effectiveness, and cost-effectiveness of a community-based lifestyle modification program for type 2 diabetes prevention.
To inform policy changes and practical methods for wider implementation.

Main Methods:

The Sydney Diabetes Prevention Program (SDPP) involved 1,550 high-risk participants (aged 50-65, including 100 Indigenous individuals).
Intervention included individual and group sessions focusing on 5% weight loss, 210 min/week physical activity, reduced fat intake (<30% energy), and increased fiber intake (≥15 g/1000 kcal).
Participants received 12 months of follow-up with 3-monthly contact for progress review and lifestyle advice.

Main Results:

Primary outcomes: changes in weight, physical activity, and dietary intake (fat, saturated fat, fiber).
Secondary outcomes: changes in waist circumference, fasting plasma glucose, blood pressure, lipids, quality of life, and health service utilization.
The study will evaluate the effectiveness and costs of the program on diabetes-related risk factors.

Conclusions:

The translational study will determine the viability and impact of a primary care-delivered lifestyle program.
Successful outcomes could lead to recommendations for broader public health initiatives to prevent or delay type 2 diabetes.