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Updated: Jun 12, 2026
09:15
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
Published on: May 7, 2019
Single-center experience in double kidney transplantation.
I Fontana1, A Magoni Rossi, G Gasloli
1Department of Transplantation, San Martino University Hospital, Genoa, Italy. iris.fontana@hsanmartino.it
Transplantation Proceedings
|June 11, 2010
Summary
This study reviewed 59 double kidney transplants (DKT) using marginal donor organs. Results show good patient and graft survival, demonstrating DKT
Area of Science:
- Nephrology
- Transplantation Immunology
- Organ Donation
Background:
- Expanding the organ donor pool is crucial for transplantation.
- Marginal donor organs are increasingly utilized.
- Double kidney transplantation (DKT) is a strategy for utilizing these organs.
Purpose of the Study:
- To evaluate outcomes of DKT using marginal donor organs in a single center.
- To compare monocenter versus multicenter study findings.
- To assess the efficacy of a scoring system for organ allocation.
Main Methods:
- Retrospective review of 59 DKT performed between 1999 and 2008.
- Analysis of recipient and donor characteristics, including age, HLA mismatches, and donor kidney function.
- Assessment of postoperative complications, patient, and graft survival.
Main Results:
- 3-year patient survival was 93% and graft survival was 86.3%.
- Common complications included acute tubular necrosis (37%), cyclosporine toxicity (12%), and iatrogenic diabetes (15%).
- The applied organ allocation score was effective but potentially overprotective.
Conclusions:
- DKT with marginal donor organs can achieve favorable long-term outcomes.
- Monocenter data provides valuable insights comparable to multicenter studies.
- The organ allocation scoring system is useful but may warrant refinement.
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