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Updated: Jun 12, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Bladder cancer and new drugs]
C Massard1, B Albouy, M Gross-Goupil
1Institut Gustave-Roussy, Département de médecine, université Paris-XI, Hautes-Bruyères, 94805 Villejuif, France. christophe.massard@igr.fr <christophe.massard@igr.fr>
Abstract:
Cisplatin-based chemotherapy (MVAC : cisplatin, methotrexate, adriamycin, vinblastine ; or GC : cisplatin, gemcitabine) has been the standard of care for patients with advanced urothelial tumor during the last twenty years. Greater knowledge in the molecular biology of bladder cancer lead to the identification of promising target such as EGFR, HER2, or VEGF-VEGFR pathways. The role of targeted therapies as monotherapy, in combination with chemotheray or as maintenance post-chemotherapy is currently under study.
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