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Updated: Jun 12, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Bladder cancer and new drugs]
C Massard1, B Albouy, M Gross-Goupil
1Institut Gustave-Roussy, Département de médecine, université Paris-XI, Hautes-Bruyères, 94805 Villejuif, France. christophe.massard@igr.fr <christophe.massard@igr.fr>
Bulletin Du Cancer
|June 11, 2010
Summary
Cisplatin-based chemotherapy has been standard for advanced urothelial cancer. Targeted therapies are being studied to improve treatment outcomes for bladder cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Context:
- Cisplatin-based chemotherapy regimens, such as MVAC and GC, have been the standard of care for advanced urothelial tumors for two decades.
- Advances in understanding bladder cancer's molecular biology have identified key targets like EGFR, HER2, and VEGF-VEGFR pathways.
Purpose:
- To explore the evolving landscape of advanced urothelial cancer treatment.
- To investigate the potential of targeted therapies in conjunction with or following chemotherapy.
Summary:
- While cisplatin-based chemotherapy remains a cornerstone, research is focusing on novel molecular targets.
- Targeted therapies are under investigation for their efficacy as monotherapy, in combination with chemotherapy, or as post-chemotherapy maintenance for urothelial tumors.
Impact:
- This research highlights a shift towards personalized medicine in urothelial cancer treatment.
- The findings may lead to improved therapeutic strategies and better patient outcomes in advanced bladder cancer.
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