Related Experiment Video
Updated: Jun 12, 2026
08:11
Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria
Published on: July 6, 2013
Recent advances in the field of Salmonella Typhi vaccines
Gavin K Paterson1, Duncan J Maskell
1Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. gkp27@cam.ac.uk
Human Vaccines
|June 11, 2010
Abstract:
Typhoid fever, caused by the bacterium Salmonella enterica serovar Typhi, remains a significant cause of human death and disease throughout large areas of the world. Although there are currently three vaccines available against S. Typhi they have a number of significant drawbacks which drive the development of much-needed new and improved versions. Here recent advances towards such vaccines, from basic research to human trials, are discussed.
Related Concept Videos
01:51Vaccinations
Overview
01:23Vaccine Production
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...