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Neuroendocrine functions of histamine
1Department of Medical Physiology C, Panum Institute, University of Copenhagen, Denmark.
Agents and Actions. Supplements
|January 1, 1991
Summary
Histamine (HA) influences pituitary and peripheral hormone release, primarily through H1- and H2-receptors in the hypothalamus. This neurotransmitter plays a key role in stress responses and regulating hormones like ACTH and prolactin.
Area of Science:
- Neuroendocrinology
- Neuropharmacology
- Hormone Regulation
Background:
- Histamine (HA) is a neurotransmitter involved in neuroendocrine regulation.
- HA exerts a generally stimulatory, indirect effect on hormone release via hypothalamic postsynaptic receptors.
Purpose of the Study:
- To elucidate the role of histamine in regulating pituitary and peripheral hormone secretion.
- To investigate the receptor subtypes (H1 and H2) mediating these effects.
- To explore histamine's involvement in stress-induced hormone release.
Main Methods:
- Review of existing literature on histamine's effects on hormone release.
- Analysis of receptor subtype involvement (H1, H2) in various pathways.
- Examination of histamine's role in stress response mechanisms.
Main Results:
- Histamine stimulates the release of ACTH, beta-endorphin, and alpha-MSH via H1 and H2 receptors, likely involving CRH and vasopressin.
- Histamine influences prolactin release through both H1 and H2 receptors, impacting dopaminergic, serotoninergic, and vasopressinergic neurons.
- Histamine stimulates vasopressin, oxytocin, catecholamines, and renin release, with central histaminergic neurons implicated in stress-induced responses.
Conclusions:
- Histamine is a significant modulator of both pituitary and peripheral hormone secretion.
- Histamine receptor subtypes H1 and H2 are critical for mediating these diverse hormonal effects.
- Histaminergic pathways are integral to the body's response to stress, affecting multiple hormone systems.
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