Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Experimental retinal branch vein occlusion].

M Minamikawa1, K Yamamoto, H Okuma

  • 1Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.

Nippon Ganka Gakkai Zasshi
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative Three-Dimensional Assessment of the Pharmacokinetic Parameters of Intra- and Peri-tumoural Tissues on Breast Dynamic Contrast-Enhanced Magnetic Resonance Imaging.

Journal of digital imaging·2021
Same author

A multiparametric classification system for lesions detected by breast magnetic resonance imaging.

European journal of radiology·2020
Same author

Sudden onset of sleep due to hypothalamic lesions in neuromyelitis optica spectrum disorder positive for anti-aquaporin-4 antibody.

Multiple sclerosis (Houndmills, Basingstoke, England)·2014
Same author

Muscle metabolism in patients with polymyositis simultaneously evaluated by using 31P-magnetic resonance spectroscopy and near-infrared spectroscopy.

International journal of clinical practice·2006
Same author

Salivary bisphenol-A levels detected by ELISA after restoration with composite resin.

Journal of materials science. Materials in medicine·2005
Same author

[Experimental retinal branch vein occlusion. 4. Pathological changes in the middle and late stage].

Nippon Ganka Gakkai zasshi·1993

Laser photocoagulation in monkeys models experimental retinal branch vein occlusion. Early signs include venous dilation, edema, hemorrhage, and blood-retinal barrier breakdown, leading to thrombi formation.

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Retinal Research

Context:

  • Retinal branch vein occlusion (RBVO) is a common vascular disorder.
  • Understanding the early pathogenesis of RBVO is crucial for developing effective treatments.
  • Previous studies have focused on clinical manifestations, with limited ultrastructural detail in early stages.

Purpose:

  • To investigate the early structural and ultrastructural changes following experimental retinal branch vein occlusion in a primate model.
  • To elucidate the sequence of events leading to blood-retinal barrier breakdown and thrombus formation.

Summary:

  • Experimental RBVO was induced using yellow wavelength (577nm) dye laser photocoagulation in Macaca irus monkeys.
  • Immediate findings included venous dilatation, retinal edema, and hemorrhage from small venules.

Related Experiment Videos

  • Electron microscopy revealed opening of intercellular junctions, signifying blood-retinal barrier breakdown, followed by endothelial cell degeneration, thrombus formation, and extravascular leakage.

    • Impact:

    • Provides detailed ultrastructural insights into the early pathogenesis of retinal branch vein occlusion.
    • Highlights the critical role of blood-retinal barrier disruption in the development of RBVO.
    • Informs potential therapeutic strategies targeting early vascular changes and barrier integrity.