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Serum C peptide level and renal function in diabetes mellitus
M N Chowta1, P M Adhikari, N K Chowta
1Department of Pharmacolgy, Kasturba Medical College, Mangalore, India.
Indian Journal of Nephrology
|June 11, 2010
Summary
Serum C-peptide levels show a weak association with kidney function and albuminuria in type 2 diabetes patients. Lower C-peptide levels correlate with increased risk of albuminuria and longer diabetes duration.
Area of Science:
- Nephrology
- Endocrinology
- Diabetology
Background:
- C-peptide is an active peptide hormone with known physiological effects.
- C-peptide can reduce glomerular hyperfiltration and urinary albumin excretion in diabetes.
Purpose of the Study:
- To correlate serum C-peptide levels with renal clearance, urinary albumin excretion, and diabetes duration.
- To investigate the association between C-peptide and markers of kidney damage in type 2 diabetes.
Main Methods:
- Prospective cross-sectional study of 168 type 2 diabetes patients (age >18).
- Measured fasting serum C-peptide, HbA1c, serum creatinine, blood urea nitrogen, urine albumin, and creatinine.
- Calculated creatinine clearance using the Modification of Diet in Renal Disease (MDRD) formula.
Main Results:
- A weak, non-significant negative correlation was observed between serum C-peptide and creatinine clearance.
- Serum C-peptide showed a negative correlation with urine albumin, urine albumin-to-creatinine ratio, HbA1c, and diabetes duration.
- Patients with subnormal C-peptide levels had higher mean urine albumin and longer disease duration.
Conclusions:
- Serum C-peptide levels have a weak association with microalbuminuria and creatinine clearance in type 2 diabetes.
- Lower serum C-peptide levels are linked to an increased risk of albuminuria and longer diabetes duration.
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