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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

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Related Experiment Videos

Built environment and diabetes.

Sudhir Kumar Pasala1, Allam Appa Rao, G R Sridhar

  • 1Department of Architecture, Andhra University College of Engineering (Autonomous), Visakhapatnam, India.

International Journal of Diabetes in Developing Countries
|June 11, 2010
PubMed
Summary

The built environment significantly impacts type 2 diabetes mellitus risk by influencing physical activity and stress. Understanding these connections is crucial for developing preventative strategies, especially in genetically susceptible populations.

Keywords:
Diabeteslifestyleobesityrelaxationsedentarysleepstress

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Area of Science:

  • Environmental Health
  • Epidemiology
  • Public Health

Background:

  • The built environment, encompassing human-modified surroundings like urban areas and access to amenities, plays a role in health outcomes.
  • Factors within the built environment, such as opportunities for physical activity and stress-inducing elements affecting sleep, are linked to the development of type 2 diabetes mellitus.
  • Globalization may lead to the adoption of Western environmental models in developing nations like India, potentially exacerbating diabetes risk due to genetic predispositions.

Purpose of the Study:

  • To review existing literature on the association between the built environment and type 2 diabetes mellitus.
  • To identify key environmental factors contributing to diabetes development.
  • To inform strategies for modifying built environments to mitigate diabetes risk.

Main Methods:

  • Systematic review of published research on built environment and diabetes.
  • Analysis of studies examining physical activity access, stress, and sleep disruption in relation to diabetes.
  • Synthesis of evidence regarding environmental influences on diabetes mellitus.

Main Results:

  • The built environment influences type 2 diabetes mellitus development through pathways including physical activity access and stress-related sleep cycle disruption.
  • Urbanization and pollution are identified as significant environmental contributors.
  • Evidence suggests a heightened susceptibility in populations with genetic predispositions when exposed to adverse built environments.

Conclusions:

  • Built environment modifications are essential for diabetes prevention.
  • Targeting physical activity promotion and stress reduction within urban planning can lower type 2 diabetes mellitus incidence.
  • Public health interventions should consider environmental factors, particularly in vulnerable populations.