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Related Experiment Videos

Nicardipine and vascular hypertrophy.

F Amenta1, E Bronzetti, F Ferrante

  • 1Department of Public Health and Cell Biology, Tor Vergata University, Rome, Italy.

American Heart Journal
|July 1, 1991
PubMed
Summary

Nicardipine treatment in spontaneously hypertensive rats significantly lowered blood pressure and reversed hypertension-induced cardiovascular changes. This calcium channel blocker effectively counteracted vascular remodeling in coronary, renal, and pulmonary systems.

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Area of Science:

  • Cardiovascular Pharmacology
  • Hypertension Research
  • Vascular Biology

Background:

  • Spontaneously hypertensive rats (SHRs) exhibit significant cardiovascular and vascular remodeling.
  • Hypertension leads to detrimental changes in coronary, renal, and pulmonary vascular morphology.
  • Understanding the impact of antihypertensive drugs on vascular structure is crucial.

Purpose of the Study:

  • To investigate the effects of nicardipine on the morphology of coronary, renal, and pulmonary vascular trees in SHRs.
  • To determine if nicardipine can counteract hypertension-dependent vascular changes.

Main Methods:

  • Male 10-week-old SHRs were administered 1 mg/kg/day of nicardipine or vehicle orally for 12 weeks.
  • Age-matched Wistar-Kyoto rats served as normotensive controls.

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  • Measurements included blood pressure, heart weight, heart/body weight ratio, medial layer area, and vascular wall/lumen area ratio.

    • Main Results:

    • SHRs showed significantly increased blood pressure, heart weight, medial layer area, and vascular wall/lumen ratio compared to controls.
    • Nicardipine treatment reduced blood pressure, relative heart weight, vascular smooth muscle area, and vascular wall/lumen ratio in SHRs.
    • Pulmonary artery smooth muscle laminae size decreased, with coronary artery branches being most sensitive to nicardipine.

    Conclusions:

    • Nicardipine effectively reduces blood pressure in SHRs.
    • Nicardipine administration counteracts hypertension-induced morphological changes in the cardiovascular system, particularly in coronary arteries.
    • These findings highlight nicardipine's potential to mitigate vascular remodeling associated with hypertension.