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Updated: Jun 12, 2026

Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
Hormonal influences on cognition and risk for Alzheimer's disease
Sarah C Janicki1, Nicole Schupf
1G. H. Sergievsky Center, Columbia University Medical Center, 622 West 168th Street, PH-19, New York, NY 10019, USA. scj2110@columbia.edu
Abstract:
Research increasingly suggests that changes in estrogen levels during aging may increase the risk of Alzheimer's disease, the most common type of dementia. This update reviews the newest information about estrogen and cognitive aging, including information regarding the role of bioavailable estrogen in older women and men, use of selective estrogen receptor modulators to improve cognition, and studies of genetic risk factors to elucidate the effects of endogenous estrogen on aging and cognition. Future trials are needed to determine whether alternate timing, dosage, formulation, or method of administration of hormone replacement can reduce the risk of dementia.
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