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Serum testosterone and short-term mortality in men with acute myocardial infarction

Constantin Militaru1, Ionut Donoiu, Ovidiu Dracea

  • 1Craiova Cardiology Center, Romania.

Cardiology Journal
|June 11, 2010
PubMed

Insights

Low testosterone levels in men with acute myocardial infarction are linked to higher short-term mortality. This study investigated the association between serum testosterone and 30-day mortality in these patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Men's Health

Background:

  • Previous studies suggest an inverse relationship between testosterone levels and cardiovascular mortality in men.
  • However, large prospective studies have not confirmed a significant association between testosterone and coronary events.

Purpose of the Study:

  • To investigate the relationship between serum testosterone levels and short-term (30-day) mortality in male patients diagnosed with acute myocardial infarction.

Main Methods:

  • 126 male patients admitted with acute myocardial infarction were included.
  • Serum free testosterone (T) levels were measured at admission using a chemiluminescence assay.
  • 30-day mortality was analyzed along with other biomarkers like hs-CRP, NT-proBNP, and HbA1c.

Main Results:

  • The mean serum T level was 4.1 +/- 2.9 ng/mL.
  • All patients who did not survive the 30-day period had a T level of less than or equal to 3 ng/mL.
  • A low serum T level was found to be independently associated with total short-term mortality.

Conclusions:

  • Low serum testosterone levels are independently associated with increased short-term mortality in men with acute myocardial infarction.
  • Testosterone levels may serve as a prognostic marker for short-term outcomes in male myocardial infarction patients.
Abstract

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