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Updated: Jun 12, 2026

Sheathless Capillary Electrophoresis–Mass Spectrometry for Metabolic Profiling of Biological Samples
Published on: October 1, 2016
Capillary electrophoresis-mass spectrometry for the analysis of amino acids
Claudia Desiderio1, Federica Iavarone, Diana Valeria Rossetti
1Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, c/o Istituto di Biochimica e Biochimica Clinica, Facoltà di Medicina, Università Cattolica, Roma, Italy.
Abstract:
In this review, the recent contribution of CE-MS technology to the analysis of amino acids, as well as the advantages of the hyphenation and the technologies involved in the instrumental coupling are reported. Different sections are dedicated to the recent contributions of CE-MS to the analysis of protein amino acids and their post-translational modifications, such as phosphorylation and sulfation. CE-MS analysis of some amino acid derivatives, such as the free methylated-derivatives of arginine is also discussed. A section is specifically devoted to the CE-MS applications in the field of chiral separation of D- and L-amino acid enantiomers.
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