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Updated: Jun 12, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
[Clinical development of biomarkers for personalized medicine]
Mayuko Saito1, Takayuki Yoshino
1Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East.
Abstract:
Recent progress in a number of molecular profiling technologies and molecular target agents allow the development of personalized medicine. Biomarkers play a critical role in drug discovery, development, and prediction of treatment response and safety. Reliable biomarkers improve disease understanding, and make it possible to tailor medication use in individual patients with the goals of enhancing efficacy and minimizing toxicity. Recently, several important breakthroughs have occurred, such as the identification of a mechanism of resistance to EGFR monoclonal antibodies in colorectal cancer, which may be followed by further predictive tests leading to a reduction of ineffective therapies. This paper focuses on the state of the biomarkers and its clinical applications for personalized medicine.
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