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Updated: Jun 12, 2026
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
[Current strategies of primary therapy for breast cancer]
Tetsu Hayashida1, Hiromitsu Jinno, Michio Sakata
1Department of Surgery, School of Medicine, Keio University.
Abstract:
Active clinical researches for breast cancer advance the therapeutic strategies remarkably, however, it seems to be more difficult to choose the appropriate treatment based on the evidence for each patient due to its diversification. Moreover, the striking achievements of various molecular targeting drugs established by basic researches make it complex, since the biological feature of tumor cell must be considered carefully for drug selection. To make it straight, the latest strategies for breast cancer treatment based on both basic and clinical evidences are summarized, especially about surgical and medical treatments of primary therapy for breast cancer.
Insights
Choosing the best breast cancer treatment is complex due to diverse options and targeted drugs. This summary covers the latest surgical and medical strategies for primary breast cancer therapy.
Area of Science:
- Oncology
- Medical Research
Context:
- Breast cancer treatment is advancing rapidly with new therapeutic strategies.
- The diversification of treatments and molecular targeting drugs complicates patient-specific therapy selection.
- Understanding tumor biology is crucial for effective drug selection in breast cancer management.
Purpose:
- To summarize the latest evidence-based strategies for primary breast cancer treatment.
- To provide an overview of current surgical and medical therapeutic approaches.
- To aid clinicians in selecting appropriate treatments based on diverse patient and tumor characteristics.
Summary:
- Reviews recent clinical research and basic science findings in breast cancer therapy.
- Highlights the complexity introduced by molecularly targeted drugs and the need for personalized medicine.
- Focuses on primary treatment modalities, including surgical interventions and systemic medical therapies.
Impact:
- Facilitates informed decision-making for clinicians managing primary breast cancer.
- Aims to optimize patient outcomes by aligning treatment with individual biological profiles.
- Contributes to the evolving landscape of breast cancer care by synthesizing current evidence.
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