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Updated: Jun 12, 2026

Whole-cell Patch-clamp Recordings in Brain Slices
Published on: June 15, 2016
[The temperature regulation of the spontaneous activity frequency and the concomitant changes of the cortical
Abstract:
In the sensorimotor cortical slices of guinea pigs, the rate of neurons' spike activity increased at 27-29 and 34-36 degrees C. The change of the firing rate was accompanied by a drop in the spike amplitude at the temperature below 27 and above 34 degrees C. Usually after cooling to 24 degrees C the spike amplitude fully restored when the temperature increased to 32-34 degrees C. The fall of spike amplitude at t >35 degrees C could not be stopped by temperatyre decrease. The data obtained indicate the important role of the neuron membrane K+ permeability.
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