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$MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor$

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Bilateral thalamic lesions.

G Menon¹, S Nair, J Sudhir

¹Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences, & Technology, Trivandrum, India. neuron1967@gmail.com

British Journal of Neurosurgery

|June 12, 2010

Summary

This summary is machine-generated.

Bilateral thalamic lesions, often low-grade gliomas, present with increased intracranial pressure and neurological deficits. These rare tumors show limited response to adjuvant therapy, indicating a poor prognosis.

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Area of Science:

Neuro-oncology
Neurosurgery
Radiology

Background:

Bilateral thalamic lesions are rare and poorly understood neoplasms.
Understanding their characteristics is crucial for diagnosis and management.

Purpose of the Study:

To present and analyze a series of nine cases of bilateral thalamic lesions.
To review the clinical, radiological, and histopathological features of these rare tumors.

Main Methods:

Retrospective analysis of nine patients with bilateral thalamic lesions.
Minimum 1-year follow-up for all cases.
Review of radiological imaging, clinical presentation, and histopathology.

Main Results:

Seven patients presented with radiological evidence of bilateral thalamic lesions; two developed contralateral involvement later.
Common symptoms included raised intracranial pressure, focal motor deficits, and behavioral changes.
Histopathology confirmed low-grade fibrillary astrocytoma in six biopsied cases; three patients had stable disease, four showed progression, and two died.

Conclusions:

Primary bilateral thalamic lesions exhibit distinct neuroradiological features.
Histologically, they are predominantly gliomas, with limited surgical options beyond biopsy and CSF diversion.
These lesions are largely unresponsive to adjuvant therapies, carrying a poor prognosis.