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Related Experiment Video

Updated: Jun 12, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Published on: July 17, 2020

SHIP2 and its involvement in various diseases.

Akira Suwa¹, Takeshi Kurama, Teruhiko Shimokawa

¹Astellas Pharma, Inc., Pharmacology Research Labs, Drug Discovery Research, 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. akira.suwa@jp.astellas.com

Expert Opinion on Therapeutic Targets

|June 12, 2010

Summary

Inositol polyphosphate 5-phosphatase (SHIP2) regulates cell signaling. Inhibiting SHIP2 shows therapeutic potential for type 2 diabetes, cancer, and neurodegenerative diseases.

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The ITS2 Database

The ITS2 Database

Published on: March 12, 2012

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Last Updated: Jun 12, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Published on: July 17, 2020

The ITS2 Database

The ITS2 Database

Published on: March 12, 2012

Area of Science:

Biochemistry
Molecular Biology
Pharmacology

Background:

Inositol polyphosphate 5-phosphatase (SHIP2) negatively regulates intracellular phosphatidylinositol phosphate, a critical second messenger.
SHIP2 upregulation disrupts signaling pathways, contributing to various disease states.

Purpose of the Study:

To review the role of SHIP2 in insulin signaling and type 2 diabetes, including pharmacological strategies.
To highlight SHIP2's involvement in cancer, neurodegenerative diseases, and atherosclerosis.

Main Methods:

Literature review focusing on SHIP2's phosphatase activity and scaffolding functions.
Analysis of recent findings on SHIP2 inhibitors and disease associations.

Main Results:

Small-molecule inhibitors targeting SHIP2 phosphatase activity demonstrate therapeutic promise.
SHIP2's scaffolding protein function is crucial for understanding its role in diverse disorders.

Conclusions:

SHIP2 is a viable therapeutic target for type 2 diabetes, cancer, neurodegenerative diseases, and atherosclerosis.
Targeting SHIP2 with specific inhibitors offers potential benefits for these conditions.