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Orofacial and systemic manifestations in 212 paediatric HIV patients from Chennai, South India
Kannan Ranganathan1, Elumalai Geethalakshmi, Umadevi Krishna Mohan Rao
1Department of Oral Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, India. ranjay22@gmail.com
Insights
Oral lesions are common in children with HIV, affecting over half of those studied. These oral manifestations often correlate with systemic lesions, highlighting the need for integrated care.
Area of Science:
- Paediatric infectious diseases
- Oral medicine
- HIV/AIDS research
Background:
- Paediatric HIV infection presents diverse oral and systemic lesions, differing from adults.
- Limited data exists on oral lesions in Indian paediatric HIV population.
Purpose of the Study:
- To document and analyze oral and systemic lesions in HIV-seropositive children.
- To understand the prevalence and types of oral manifestations in this demographic.
Main Methods:
- A cross-sectional study involving 212 paediatric HIV patients (0-14 years).
- Clinical history and oral/systemic examinations conducted by dental surgeons and physicians.
- Data collected from tertiary centers in Chennai, India.
Main Results:
- 132 patients (62.3%) had oral lesions, most commonly oral candidiasis (56.1%).
- Common systemic lesions included lymphadenopathy (74.1%) and pruritic eruptions (53.8%).
- Oral lesions showed a positive correlation with systemic lesions.
Conclusions:
- Oral lesions are a frequent occurrence in paediatric HIV infection.
- Effective management of oral lesions is crucial for improving children's quality of life.
- Further research on oral health in paediatric HIV is warranted.
Background:
Lesions in the mouth and in other tissues and organs (oral and systemic lesions) in paediatric HIV infection are diverse and show differences in clinical presentation and severity from that of adults. Very little data exist for oral lesions in paediatric population in India.
Aim:
To document and study oral and more widespread lesions in paediatric HIV seropositive patients.
Design:
A cross-sectional study.
Setting:
Paediatric HIV seropositive patients at tertiary centers: Ragas Dental College and Hospital and YRG CARE, Chennai, India.
Patients And Methods:
Two hundred and twelve paediatric HIV patients aged 0-14 years seen over a period of 1 year were included in the study. Clinical history, oral and systemic examinations were recorded by qualified dental surgeons and physicians.
Results:
One hundred and thirty-two patients had oral lesions ranging in number from one to three. Oral lesions included oral candidiasis (OC) (56.1%), gingivitis (10.8%), oral pigmentation (6.1%), depapillation of the tongue (5.7%), ulcers (4.2%), and oral hairy leukoplakia (1.4%). The most common systemic lesion observed was nonspecific lymphadenopathy (74.1%) followed by pruritic eruptions (53.8%), measles (51.4%), and tuberculosis (TB) (49.1%). Thirty-three (26%) patients were not immunosuppressed, 74 (58%) were moderately immunosuppressed, and 20 (15%) were severely immunosuppressed. Oral lesions exhibited positive correlation with lesions in other parts of the body.
Conclusion:
Oral lesions are a common feature in paediatric HIV infection. Their management is vital to improve the quality of life of the infected children.
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