Related Experiment Video
Updated: Jun 12, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Potential role of immunosenescence in cancer development
Tamas Fulop1, Rami Kotb, Carl F Fortin
1Research Center on Aging, Department of Medicine, University of Sherbrooke, Sherbrooke, Canada. tamas.fulop@usherbrooke.ca
Abstract:
The incidence and prevalence of most cancers increase with age. The reasons for this may include tumor escape mechanisms and decreased immunosurveillance, but most are caused by the time required for carcinogenesis, according to most scientists. The immune system is a unique mechanism of defense against pathogens and possibly cancers; however, there is a body of evidence that the immune system of the aged is eroded, a phenomenon termed immunosenescence. There is a growing interest in immunosenescence and how it may contribute to the increased number of cancers with aging. Each arm of the immune system, innate and adaptive, is altered with aging, contributing to increased tumorigenesis. Understanding the contribution of immunosenescence to cancer development and progression may lead to better interventions for the elderly.
Related Concept Videos
Tumor Immunotherapy
Psychoneuroimmunology: Diabetes and Cancer
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Cancer Prevention
Some...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...