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Related Concept Videos

Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:â—Ź Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
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Hypoxia01:23

Hypoxia

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Peroxisomes01:24

Peroxisomes

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Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
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Hyperbaric oxygen treatment induces antioxidant gene expression.

Cassandra A Godman1, Rashmi Joshi, Charles Giardina

  • 1Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.

Annals of the New York Academy of Sciences
|June 12, 2010
PubMed
Summary

Hyperbaric oxygen therapy may promote healthy aging by inducing protective responses in endothelial cells. This mild stress enhances cellular resistance to oxidative damage, potentially aiding wound healing in older individuals.

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Published on: February 7, 2018

Area of Science:

  • Cellular and Molecular Biology
  • Aging Research
  • Hyperbaric Medicine

Background:

  • Aging is associated with declining cellular functions, including impaired wound healing and angiogenesis, particularly in older individuals with chronic wounds.
  • Hormetic agents, such as exercise and calorie restriction, can induce protective cellular responses through mild oxidative stress, promoting healthy aging.
  • Hyperbaric oxygen therapy (HBOT) is explored as a potential hormetic stressor to enhance cellular resilience.

Purpose of the Study:

  • To investigate the effects of HBOT on gene expression in human microvascular endothelial cells.
  • To determine if HBOT confers protection against oxidative stress in these cells.
  • To assess HBOT's potential as a hormetic treatment for promoting healthy aging and improving wound healing.

Main Methods:

  • Human microvascular endothelial cells were exposed to hyperbaric oxygen at a level comparable to clinical treatment.
  • Global gene expression profiling was performed to identify changes in gene activity post-exposure.
  • Cells were subsequently subjected to lethal oxidative stress to assess their resistance.

Main Results:

  • Hyperbaric oxygen exposure led to the upregulation of genes involved in antioxidant defense, cellular protection, and immediate early response pathways.
  • This upregulation of protective genes correlated with enhanced resistance of endothelial cells to severe oxidative stress.
  • The findings suggest a hormetic effect of HBOT on endothelial cells.

Conclusions:

  • Hyperbaric oxygen can induce a protective response in human microvascular endothelial cells against oxidative insults.
  • HBOT may serve as an accessible hormetic treatment to support healthy aging and improve outcomes for conditions like chronic wounds.
  • Further research into HBOT's role in aging and regenerative medicine is warranted.