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Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Related Experiment Videos

Bone cancer pain.

Juan Miguel Jimenez-Andrade1, William G Mantyh, Aaron P Bloom

  • 1Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.

Annals of the New York Academy of Sciences
|June 12, 2010
PubMed
Summary
This summary is machine-generated.

Bone cancer pain, common in advanced cancers, is poorly understood. New models offer insights into pain mechanisms and guide the development of novel, mechanism-based therapies for improved patient outcomes.

Related Experiment Videos

Area of Science:

  • Oncology
  • Pain Medicine
  • Skeletal Biology

Background:

  • Cancer is a leading cause of death in the US, with bone metastases frequent in advanced breast, prostate, and lung cancers.
  • Bone metastases significantly increase morbidity and mortality through skeletal remodeling, fractures, pain, and anemia.
  • The underlying mechanisms driving bone cancer pain remain largely unclear.

Purpose of the Study:

  • To investigate the mechanisms driving bone cancer pain.
  • To utilize novel preclinical models that accurately replicate human bone cancer pain.
  • To guide the development of targeted, mechanism-based pain therapies.

Main Methods:

  • Development and utilization of advanced preclinical models of bone cancer pain.
  • Analysis of skeletal remodeling, pain behaviors, and associated physiological changes in these models.
  • Translational research to inform human clinical trials.

Main Results:

  • Preclinical models provide crucial insights into the biological drivers of bone cancer pain.
  • These models facilitate the identification of therapeutic targets for pain management.
  • Emerging therapies derived from these studies are progressing to clinical trials.

Conclusions:

  • Understanding bone cancer pain mechanisms is critical for effective treatment.
  • Mechanism-based therapies show promise in improving quality of life for cancer patients.
  • Successful clinical translation could significantly enhance cancer pain management strategies.