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Updated: Jun 12, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Plasmablastic lymphomas with light chain restriction - plasmablastic extramedullary plasmacytomas?

Sonja C Boy1, Marlene B van Heerden, Erich J Raubenheimer

  • 1Department of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, South Africa. sonja.boy@up.ac.za

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|June 12, 2010
PubMed
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Plasmablastic lymphomas (PBLs) often show plasmacytic differentiation, challenging current classifications. Light chain restriction suggests reclassifying some PBLs as extramedullary plasmacytomas for appropriate management.

Area of Science:

  • Oral Pathology
  • Hematopathology
  • Oncology

Background:

  • Differentiating plasmablastic lymphomas (PBLs) from plasma cell neoplasms with plasmablastic features is diagnostically challenging.
  • Current classifications include 'PBL of the oral mucosa' and 'PBL with plasmacytic differentiation', which may not accurately reflect the spectrum of these neoplasms.

Purpose of the Study:

  • To investigate the immunophenotypic and molecular characteristics of PBLs.
  • To evaluate the validity of current morphological classifications for PBLs.
  • To propose refined classification and management strategies for PBLs.

Main Methods:

  • Retrospective analysis of 45 PBL cases from South African institutions.
  • Clinical data, including HIV status, were collected.

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  • Immunohistochemistry (CD45, CD3, CD20, CD79a, CD38, CD138, MUM1, Ki-67, kappa/lambda light chains) and in situ hybridization for Epstein-Barr virus (EBV) and HHV-8 were performed.

    • Main Results:

    • All cases exhibited some degree of plasmacytic differentiation and were negative for CD20, with reactive T cells (CD3+).
    • Strong positivity for Ki-67 and MUM1 was observed, with variable expression of CD79a, CD45, CD38, and CD138.
    • Epstein-Barr virus (EBV) was detected in 44/45 cases; HHV-8 was negative in all cases. Light chain restriction was present in 47% of cases.

    Conclusions:

    • The morphological classification of PBLs is inadequate, as all cases demonstrated plasmacytic differentiation.
    • PBLs with light chain restriction warrant reclassification as 'plasmablastic extramedullary plasmacytomas' and require distinct management.
    • Further molecular and genetic studies are essential to elucidate the true nature of these neoplasms.