Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurons: The Axon01:21

Neurons: The Axon

Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Neuron Structure01:30

Neuron Structure

Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to cellular...
Neuron Structure01:31

Neuron Structure

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial Subdomains in the Optic Tectum for the Encoding of Visual Information.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Strikingly different neurotransmitter release strategies in dopaminergic subclasses.

eLife·2025
Same author

U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis.

bioRxiv : the preprint server for biology·2025
Same author

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.

Nature neuroscience·2025
Same author

Functional Maturation and Experience-Dependent Plasticity in Adult-Born Olfactory Bulb Dopaminergic Neurons.

The European journal of neuroscience·2025
Same author

A workflow for semi-automated volume correlative light microscopy and transmission electron tomography.

Journal of microscopy·2025
Same journal

Population codes for context-dependent decision-making.

Current opinion in neurobiology·2026
Same journal

Cichlid fish as a model for understanding social dysfunction.

Current opinion in neurobiology·2026
Same journal

On aims and methods in field neuroethology: Investigating neural mechanisms of behavior in semi-natural and natural contexts.

Current opinion in neurobiology·2026
Same journal

Neurobiological interfaces connecting environmental change to monarch butterfly migration.

Current opinion in neurobiology·2026
Same journal

Learning how to experience the world: From circuits to cell types to genes.

Current opinion in neurobiology·2026
Same journal

Editorial overview for neurobiology of disease 2026.

Current opinion in neurobiology·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments
06:53

Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments

Published on: February 12, 2021

Building and maintaining the axon initial segment.

Matthew S Grubb1, Juan Burrone

  • 1MRC Centre for Developmental Neurobiology, King's College London, 4th Floor, New Hunt's House, Guy's Campus, London SE1 1UL, UK. matthew.grubb@kcl.ac.uk

Current Opinion in Neurobiology
|June 12, 2010
PubMed
Summary
This summary is machine-generated.

The axon initial segment (AIS) initiates action potentials and controls neuronal identity. Recent studies reveal its distinct domains, role as a transport barrier, and plasticity in response to neuronal activity.

Failed At:

2026-06-19T13:36:26.427667+00:00

More Related Videos

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy (3D-SIM)
07:40

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy (3D-SIM)

Published on: February 11, 2022

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth
11:46

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

Published on: August 10, 2011

Related Experiment Videos

Last Updated: Jun 12, 2026

Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments
06:53

Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments

Published on: February 12, 2021

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy (3D-SIM)
07:40

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy (3D-SIM)

Published on: February 11, 2022

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth
11:46

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

Published on: August 10, 2011