Related Experiment Video
Updated: Jun 12, 2026
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Active hydrodissection might optimize cryosurgical ablation of the prostate
Gene S Rosenberg1, Kevin G Basralian
1Department of Urology, Hackensack University Medical Center, Holy Name Hospital, Teaneck, New Jersey, USA. drgrose@aol.com
Objective:
To produce lower temperatures safely in the prostate, and better protect the rectum , as well as maximize the technique of cryosurgical ablation to better eradicate prostate cancer.
Methods:
A total of 10 consecutive patients underwent total, subtotal, or focal cryosurgical ablation, with saline hydrodissection. We found lethal prostate temperatures and safer rectal temperatures. One patient developed a very small rectourethral fistula that healed with catheter drainage alone, prompting a revised technique. The prostate-specific antigen values at short follow-up were very low.
Results:
Temperatures of -10°C to -76°C were achieved outside the prostate at the neurovascular bundle. Post-operative prostate-specific antigen values were 0.10 to 3.4 if total or focal therapy, respectively, was used. A small rectal fistula healed with catheter drainage alone.
Conclusions:
This technique appears to hold great promise and should be investigated further in a larger group of patients with longer follow-up.
