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Updated: Jun 12, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population
Qian Zhao1, Ronglin Che, Zhao Zhang
1Bio-X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong, University, PR China.
Abstract:
In the present work we genotyped three single-nucleotide polymorphisms (SNPs) (rs7301328, rs1805247, and rs1805502) of the GRIN2B gene in a set of 480 unrelated bipolar disorder patients and 480 unrelated genetically matched normal controls in Chinese Han population by either allelic-specific multiplex ligation-detection reaction (AMLR) technology or direct sequencing. Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder.
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