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Adoptive immunotherapy of cancer using ex vivo expanded human gammadelta T cells: A new approach

Pouneh Dokouhaki1, Mei Han, Betty Joe

  • 1Toronto General Research Institute, University Health Network, Toronto, Canada.

Cancer Letters
|June 12, 2010
PubMed

gammadelta T cells can be an option for adoptive immunotherapy of cancer. The major obstacle to clinical application of gammadelta T cells is their low number and lack of a reliable method to expand them consistently and efficiently. We were able to expand gammadelta T cells with high purity in all donors regardless of their starting repertoire of gammadelta T cells. These ex vivo expanded gammadelta T cells are in early differentiation stage, can efficiently kill various tumors and inhibit growth of human lung cancer xenografts. This new approach for ex vivo expansion of human gammadelta T cells will open new horizons for clinical use of these cells.

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